Chronic treatment with nandrolone decanoate reduces left ventricular contractile response even when combined with strength training.

Introduction: The use of anabolic steroids is widely adopted for aesthetic purposes and sports performance. In supraphysiological doses, they can impair various physiological systems. However, we know little about their effects on the heart, especially when combined with strength training.

PLK1 overexpression suppresses homologous recombination and confers cellular sensitivity to PARP inhibition.

The overexpression of Polo-like kinase 1 (PLK1) is associated with poor clinical outcomes in various malignancies, making it an attractive target for anticancer therapies. Although recent studies suggest PLK1's involvement in homologous recombination (HR), the impact of its overexpression on HR remains unclear. In this study, we investigated the effect of PLK1 overexpression on HR using bioinformatics and experimental approaches.

Simultaneous separation of the enantiomers of six anticoagulant rodenticides using chiral supercritical fluid chromatography-mass spectrometry.

The simultaneous separation of the enantiomers of six anticoagulant rodenticides, derived from 4-hydroxycoumarin, has been studied in this work. Ten different stationary phases (zwitterionic, Pirkle-type, polysaccharides and macrocyclic antibiotics derivatives) were evaluated by using supercritical fluid chromatography coupled to two different detectors (circular dichroism and mass spectrometry-single quadrupole). The effect of the type of organic modifier and temperature on the chiral separation was investigated, and the best results were obtained with the column Regis S,S-Whelk-O1 at 25 °C when using a gradient elution program with methanol as organic modifier.

The effect of body position on cardiovascular, skeletal muscle and ventilatory responses to submaximal cycling.

The completion of exercise in different body positions can impact the function of various components of the oxygen delivery pathway; however, the effect of the haemodynamic conditions induced by a semi-upright body position on the integrative physiological response to exercise is poorly understood. The purpose of this study was to explore the effect of a semi-upright body position on cardiac output (CO), vastus lateralis oxygen saturation ( ), oxygen consumption ( ) and ratings of perceived exertion (Borg RPE) during submaximal cycling. Twenty healthy individuals (22 ± 3 years, 50% female) each completed alternating 5-min bouts of submaximal upright and semi-upright (40° incline) cycling at 50 and 100 W.