A cross-country comparison of temporal change in adolescent mental health problems in the UK and Brazil.

Aims: Epidemiological evidence shows a concerning rise in youth mental health difficulties over the past three decades. Most evidence, however, comes from countries in Europe or North America, with far less known about changes in other global regions. This study aimed to compare adolescent mental health across two population-based cohorts in the UK, and two population-based cohorts in Pelotas, Brazil.

Robotic-assisted retroperitoneal lymph node dissection: defining selection parameters-a B-SAFE approach.

The objective of the study is to define selection parameters for RRPLND and evaluate the outcomes from cases selected via this method. Patients undergoing RRPLND from 2017 to 2023 (n = 57) were included. Initial criteria for robotic case selection were defined via 'B-SAFE' parameters.

Balancing the risk of major bleeding against vascular disease risk in people without atherosclerotic disease.

Background And Aims: In the primary prevention setting, low-dose aspirin reduces major vascular events (MVEs) by approximately 11% but increases major bleeding (MB) by 40-50%, implying that net benefit will be most evident when the MVE-to-MB ratio is >4. This study aimed to derive cross-validated risk scores for MB and MVE and use the MVE-to-MB ratio to identify groups who may derive differing net benefits from treatment.

Methods: 431 167 UK Biobank participants without known atherosclerotic cardiovascular disease at baseline were followed through record linkage for incident MVEs (myocardial infarction, non-haemorrhagic stroke, transient ischaemic attack, arterial revascularisation or vascular death) and MB (gastrointestinal and intracranial bleeds with hospital admission for ≥2 days).

Effects of aspirin and omega-3 fatty acids on age-related macular degeneration in ASCEND-Eye: a randomised placebo-controlled trial in a population with diabetes.

Purpose: Aspirin and omega-3 fatty acids (FAs) are potential disease modifiers of age-related macular degeneration (AMD), but previous studies have produced inconsistent findings. Randomised evidence for the efficacy and safety of aspirin and omega-3 FAs on AMD is presented in this study.

Design: ASCEND-Eye is a substudy of eye effects in the 2×2 factorial design ASCEND (A Study of Cardiovascular Events iN Diabetes) double-blind, randomised, placebo-controlled trial for the primary prevention of cardiovascular events.

Technological and Socio-Demographic Factors Influencing Telemedicine Literacy in Trinidad and Tobago: A Cross-Sectional Study Using Multidimensional Approach.

Background And Aims: The COVID-19 pandemic restriction impacted physical or face-to-face interactions, leading to an upsurge in the use of information technology (IT). This necessitated the adoption of various remote healthcare services including telehealth. This study aimed to examine the role of technological and socio-demographic factors in enhancing telemedicine literacy.