The Role of Machine Learning in the Detection of Cardiac Fibrosis in Electrocardiograms: Scoping Review.

Background: Cardiovascular disease remains the leading cause of mortality worldwide. Cardiac fibrosis impacts the underlying pathophysiology of many cardiovascular diseases by altering structural integrity and impairing electrical conduction. Identifying cardiac fibrosis is essential for the prognosis and management of cardiovascular disease; however, current diagnostic methods face challenges due to invasiveness, cost, and inaccessibility.

Basic Science and Pathogenesis.

Background: Alzheimer's disease (AD) stands out as the most prevalent neurodegenerative condition globally, marked by a progressive cognitive decline. Its distinctive histopathological features include neurofibrillary tangles composed of Tau protein aggregates and amyloid beta (Aβ) aggregates forming neuritic plaques in the parenchyma and cerebral amyloid angiopathy (CAA) in blood vessels. Intriguingly, it has been hypothesized that CAA induces alterations in the cells comprising the neurovascular unit (NVU), exacerbating the disease's symptoms.

Enhancing the European power system resilience with a recommendation system for voluntary demand response.

Climate change, geopolitical tensions, and decarbonization targets are bringing the resilience of the European electric power system to the forefront of discussion. Among various regulatory and technological solutions, voluntary demand response can help balance generation and demand during periods of energy scarcity or renewable energy generation surplus. This work presents an open data service called Interoperable Recommender that leverages publicly accessible data to calculate a country-specific operational balancing risk, providing actionable recommendations to empower citizens toward adaptive energy consumption, considering interconnections and local grid constraints.

Risk of bleeding with the concurrent use of amiodarone and DOACs: A systematic review and meta-analysis.

Background And Aims: Amiodarone is frequently prescribed alongside direct oral anticoagulants (DOACs) in atrial fibrillation (AF). There are concerns regarding drug-drug interactions (DDIs) between amiodarone and DOACs. The literature is conflicting on the clinical implications of this DDI, hence we conducted a meta-analysis to compare bleeding risk among patients receiving DOACs, with and without concurrent amiodarone.

Correlation of ECG and cardiac MRI for assessment of ventricular hypertrophy and dilatation in adults with repaired tetralogy of Fallot.

Background: Surgically repaired Tetralogy of Fallot (rTOF) is associated with progressive right ventricular hypertrophy (RVH) and dilation (RVD). Accurate estimation of RVH/RVD is vital for the ongoing management of this patient population. The utility of the ECG in evaluating patients with rTOF with pre-existing right bundle branch block (RBBB) has not been studied.