Publications by authors named "J Dwivedi"
Aim: To identify some novel fatty acid hydrolase (FAAH) inhibitors that may contribute to the treatment of Alzheimer's disease (AD).
Methods: In-silico pharmacophore modelling including ligand-based pharmacophore modelling, virtual screening, molecular docking, molecular dynamics modelling, density functional theory and in-silico pharmacokinetics and toxicological studies were employed for the retrieving of novel FAAH inhibitors. Further, these compounds were evaluated for FAAH inhibitory activity using an in vitro enzymatic assay, and later, an in vivo streptozotocin (STZ)-induced AD model was examined in mice.
Article Synopsis
- Gene therapy, traditionally focused on late-stage cancers and congenital disorders, is now being explored for skin and wound healing applications, revealing its broader potential.
- The complexity of cutaneous wound healing presents challenges for effective gene delivery, prompting the development of various innovative strategies including liposomal administration and nanoparticles.
- Clinical studies indicate that genetically engineered cells can facilitate the targeted delivery of growth factors, improving wound healing more effectively than traditional mechanical methods.
Aspects of β-sitosterol's Pharmacology, Nutrition and Analysis.
Curr Pharm Biotechnol
September 2024
Phytosterols are bioactive substances found naturally in the cell membranes of plants and have an arrangement of molecules similar to that of fat, which is produced by mammalian cells. They are widely distributed as dietary sources of lipids in plants, such as nuts, seeds, olive oil, and legumes. This review provides a summary of the efficacy of BS in treating lifestyle problems, as well as an appraisal of previous research.
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- The study focuses on the anti-inflammatory potential of two wild edible plants, Silene vulgaris and Stellaria media, which are abundant in the environment.
- Researchers used in-vitro COX-2 inhibitory assays to evaluate the effectiveness of these plants, discovering that their hexane fractions had significant COX-2 inhibitory activity.
- LC-MS analysis identified numerous bioactive compounds in these fractions, with specific compounds showing strong docking scores, suggesting they could potentially be developed into therapeutic options for managing inflammation.
Background: Direct current cardioversion is frequently used to return patients with atrial fibrillation (AF) to sinus rhythm. Chest pressure during cardioversion may improve the efficacy of cardioversion through decreasing transthoracic impedance and increasing cardiac energy delivery.
Objectives: This study aimed to assess the efficacy and safety of upfront chest pressure during direct current cardioversion for AF with anterior-posterior pad positioning.