Publications by authors named "J Dutrieux"
Article Synopsis
- * Human Parainfluenza Virus type 3 (HPIV-3) is frequently associated with COPD exacerbations, but its specific effects on the respiratory cells of COPD patients hadn’t been studied before this research.
- * The study found that COPD-affected respiratory cells showed heightened inflammation and a less effective antiviral response compared to healthy cells, possibly making it harder for the immune system to fight off viral infections and leading to ongoing inflammation.
Thymic activation improves the outcome of COVID-19 patients with severe pneumonia. The genetic polymorphism within the locus, which affects thymic output in healthy individuals, was found here to modify SARS-CoV-2-specific immunity and disease severity in COVID-19 patients with severe pneumonia. Forty patients with severe COVID-19 pneumonia were investigated.
View Article and Find Full Text PDFChimeric antigen receptor (CAR) T cells have shown promising results in the treatment of B-cell malignancies. Despite the successes, challenges remain. One of them directly involves the CAR T-cell manufacturing process and especially the ex vivo activation phase.
View Article and Find Full Text PDFInfection by retroviruses as HIV-1 requires the stable integration of their genome into the host cells. This process needs the formation of integrase (IN)-viral DNA complexes, called intasomes, and their interaction with the target DNA wrapped around nucleosomes within cell chromatin. To provide new tools to analyze this association and select drugs, we applied the AlphaLISA technology to the complex formed between the prototype foamy virus (PFV) intasome and nucleosome reconstituted on 601 Widom sequence.
View Article and Find Full Text PDFArticle Synopsis
- Unintegrated HIV DNA makes up 20-35% of the total viral DNA in infected patients, with linear forms (unintegrated linear DNAs or ULDs) being crucial for integration and viral replication.
- The detection of ULDs is challenging due to the limitations of existing methods, which lack specificity and sensitivity.
- A new technology called DUSQ, combining linker-mediated PCR and next-generation sequencing, has been developed for ultra-sensitive quantification of ULDs and can track pre-integrative latency in HIV-1 infected patients, with potential applications for other rare DNA molecules.