Publications by authors named "J Durrani"
Article Synopsis
- A study was conducted to evaluate the safety of immunosuppressive therapy (IST) using anti-thymocyte globulin (ATG) and cyclosporine (CSA) in older patients with severe aplastic anemia (SAA), comparing outcomes with younger patients.
- Although older patients experienced similar rates of serious adverse events (SAEs) and hospital stays as younger ones, they showed a higher incidence of cardiac events related to IST, though none were fatal.
- Despite older patients facing worse overall survival rates and more relapse or clonal evolution, those who responded well to IST had survival rates comparable to younger patients, suggesting that disease factors rather than treatment complications primarily drive the outcomes.
Background: Prediabetes is a condition preceding the development of diabetes and is associated with an increased risk of a number of complications. The primary mode of management is thought to be lifestyle modification. Pharmacological therapy, such as glucagon-like peptide-1 receptor agonists (GLP-1RAs), were not well addressed in the literature and were only evaluated in trials as secondary and exploratory outcomes with a limited sample size.
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- VEXAS syndrome is an autoinflammatory disorder linked to mutations in the UBA1 gene, with thrombosis being a significant clinical feature affecting 49% of patients.
- The majority of thrombosis cases were venous thromboembolism (VTE), often occurring unprovoked, recurrent, and sometimes even in patients on anticoagulants.
- Despite the high incidence of VTE, overall patient survival was good, with an 88% survival rate over nearly 5 years, indicating that thrombosis does not significantly impact long-term survival in these patients.
Objective: To investigate the impact of testosterone replacement therapy (TRT) on cardiovascular outcomes in hypogonadal men.
Methods: A meta-analysis of 26 randomized controlled trials involving 10 941 participants was conducted. Various clinical outcomes, including all-cause mortality, cardiovascular-related mortality, myocardial infarction, stroke, congestive heart failure, atrial fibrillation, pulmonary embolism, and venous thrombosis, were assessed.