Cardiovascular complications among hematopoietic cell transplantation survivors - the role of cardiomarkers.

Background: Allogeneic hematopoietic stem cell transplantation (HSCT) offers potentially curative therapy for numerous malignant and nonmalignant diseases. The number of survivors and length of follow-up after successful HSCT is continually increasing. HSCT can induce damage of various organs and tissues - from minimal potentially progressive subclinical changes to life-threatening conditions.

Primary thyroid leiomyosarcoma with transvenous extension to the right atrium: a case report.

Background: Primary thyroid leiomyosarcoma (LMS) is a very rare tumour with less than 40 published cases yet. Direct metastatic extension into the great cervical veins and caval veins is extremely uncommon. Extension to the right heart has not yet been reported.

FireProtDB: database of manually curated protein stability data.

The majority of naturally occurring proteins have evolved to function under mild conditions inside the living organisms. One of the critical obstacles for the use of proteins in biotechnological applications is their insufficient stability at elevated temperatures or in the presence of salts. Since experimental screening for stabilizing mutations is typically laborious and expensive, in silico predictors are often used for narrowing down the mutational landscape.

Prognostic value of echocardiography and ECG in heart failure with preserved ejection fraction.

Objective: The aim of this study was to evaluate characteristics of patients with heart failure (HF) with preserved ejection fraction (HFPEF) and to assess prognostic predictors in 2-year follow-up.

Methods: We included prospectively 109 patients admitted to the internal department for HF, grouped into HFPEF (EF>40 %, n = 63) and HF with reduced EF (HFREF) (EF≤40 %, n=46). Preserved right ventricular systolic function (PRV) was defined as the peak systolic tricuspid annular velocity (S') >10.

["3P (Patient-Pulse-Prognosis) in heart failure" survey: focus on heart rate].

Background: The data on heart rate in chronic heart failure in the real-world practice in Slovakia are not sufficiently known. The objective of the "3P (Patient-Pulse-Prognosis) in heart failure" survey was to collect epidemiological data with particular emphasis on heart rate control in sinus rhythm.

Methods: The survey was performed by 162 cardiologists and internists.