Publications by authors named "J Drenkow"

Modern maize (Zea mays ssp. mays) was domesticated from Teosinte parviglumis (Zea mays ssp. parviglumis), with subsequent introgressions from Teosinte mexicana (Zea mays ssp.

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(L.) Moench is a significant grass crop globally, known for its genetic diversity. High quality genome sequences are needed to capture the diversity.

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Article Synopsis
  • * A deep-learning model can predict allele-specific activity using only local nucleotide sequences, emphasizing key transcription-factor-binding motifs affected by genetic variants.
  • * Combining EN-TEx with previous genome annotations shows significant connections between allele-specific loci and GWAS loci, and aids in transferring known eQTLs to challenging tissue types, improving personal functional genomics research.
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Crop productivity depends on activity of meristems that produce optimized plant architectures, including that of the maize ear. A comprehensive understanding of development requires insight into the full diversity of cell types and developmental domains and the gene networks required to specify them. Until now, these were identified primarily by morphology and insights from classical genetics, which are limited by genetic redundancy and pleiotropy.

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We have produced RNA sequencing data for 53 primary cells from different locations in the human body. The clustering of these primary cells reveals that most cells in the human body share a few broad transcriptional programs, which define five major cell types: epithelial, endothelial, mesenchymal, neural, and blood cells. These act as basic components of many tissues and organs.

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