Rat Model of Endogenous and Exogenous Hyperammonaemia Induced by Different Diets.

Two different diets able to induce dietary hyperammonaemia (a methionine-choline-deficient (MCD) diet and a methionine-deficient diet enriched with ammonium acetate (MAD + 20% ammonium acetate)) were tested in a rat model. The diets were shown to have different modes of action, inducing significant hyperammonaemia (HA) and growth retardation in the rats, with different metabolic consequences. The MCD diet resulted in the development of endogenous HA, with a decrease in bilirubin levels and an increase in hepatic fat content.

Assessment of the sub-lethal impacts of Karenia brevis on hard clams, Mercenaria campechiensis.

Karenia brevis, a toxin-producing dinoflagellate, has been implicated in frequent harmful algal blooms (HABs) in the Gulf of Mexico. Shellfish species, such as Mercenaria campechiensis, have high resilience to K. brevis exposure causing high accumulation and retention of brevetoxins within their tissues.

Antisense oligonucleotide-mediated MSH3 suppression reduces somatic CAG repeat expansion in Huntington's disease iPSC-derived striatal neurons.

Expanded CAG alleles in the huntingtin () gene that cause the neurodegenerative disorder Huntington's disease (HD) are genetically unstable and continue to expand somatically throughout life, driving HD onset and progression. MSH3, a DNA mismatch repair protein, modifies HD onset and progression by driving this somatic CAG repeat expansion process. is relatively tolerant of loss-of-function variation in humans, making it a potential therapeutic target.

Evaluating the effects of dietary glutamine on performance, carcass traits, blood biochemistry, and intestine morphology in laying quail.

This study investigated the effects of dietary glutamine (Gln) supplementation on the performance, carcass characteristics, blood biochemistry, intestinal morphology, and gut microbiota of laying quail over a 12-week period, with analyses conducted after 6 and 12 weeks of supplementation. Seven-week-old dual-purpose female quails at the onset of laying were assigned to diets containing 0% (control), 0.5%, 1%, or 1.