Publications by authors named "J Donald McPhail"
Physiological Characteristics of Freestyle Snowboard and Freeski Athletes.
Int J Sports Physiol Perform
December 2024
Purpose: To investigate the physiological characteristics of freestyle snowboard and freeski athletes and explore potential differences between males and females.
Methods: National-team athletes, snowboard (9 males, 21 [2.3] y; 8 females, 20 [4.
Introduction: Alzheimer's disease (AD) and other tauopathies are characterized by intracellular aggregates of microtubule-associated protein tau that are actively released and promote proteopathic spread. Microglia engulf pathological proteins, but how they endocytose tau is unknown.
Methods: We measured endocytosis of different tau species by microglia after pharmacological modulation of macropinocytosis or clathrin-mediated endocytosis (CME) or antagonism/genetic depletion of known tau receptors heparan-sulfate proteoglycans (HSPGs) and low-density lipoprotein receptor-related protein 1 (LRP1).
Protein misfolding and aggregation is a characteristic of many neurodegenerative disorders, including Alzheimer's and Parkinson's disease. The oligomers generated during aggregation are likely involved in disease pathogenesis and present promising biomarker candidates. However, owing to their small size and low concentration, specific tools to quantify and characterize aggregates in complex biological samples are still lacking.
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- Patients with prostate cancer experience significant sexual dysfunction following treatment, impacting their mental health and relationships.
- An international panel created guidelines to help clinicians and patients understand the effects of prostate cancer treatments on sexual health and relationships, emphasizing the importance of biopsychosocial rehabilitation for survivors.
- The guidelines were developed through a systematic literature review, considering cultural diversity and the unique needs of various sexual orientations and gender identities, aimed at fostering open discussions about sexual health outcomes.
Background: Associated with considerable risk of morbidity, Total Pelvic Exenteration (TPE) is a life-altering procedure involving a significant prolonged recovery. As a result, and with the view of achieving the best outcomes and lessen short and long-term morbidities, a well-thought-out and coordinated multidisciplinary team approach, is crucial to the provision of safe and high-quality care.
Method: Using a nominal group technique and qualitative methodology, this article explores the current practices in the care of oncology patients who undergo TPE surgery, in a tertiary cancer centre, by highlighting considerations of a collaboratively multi-disciplinary team.