Publications by authors named "J Donald Easton"
Article Synopsis
- c-MYC is a crucial factor in the development of high-risk neuroblastoma, and the lack of mouse models has limited research on its mechanisms and therapy development.
- Inducing c-MYC through different promoters showed varied tumor types: using a tyrosine hydroxylase promoter led to pancreatic tumors, while a dopamine β-hydroxylase promoter resulted in neuroblastoma.
- The neuroblastoma tumors in mice exhibited similar characteristics to human neuroblastoma and responded to existing treatments, highlighting the importance of these models for testing new therapies.
Background: The treatment approach for soft tissue sarcomas (STS) of the lower extremity has shifted toward the use of neoadjuvant radiation combined with limb-sparing surgery (LSS). The resulting defects often require reconstruction with free tissue transfer for adequate outcomes. Data have demonstrated a potentially increased risk of microvascular complications for free flaps performed using irradiated recipient vessels.
View Article and Find Full Text PDFTime to treatment and disability attributed to index stroke in the POINT trial.
J Stroke Cerebrovasc Dis
November 2024
Background: In the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) trial, dual antiplatelet therapy (DAPT) was associated with reduced disability attributable to the index stroke compared to antiplatelet monotherapy. However, it is unknown whether earlier treatment with DAPT versus aspirin is associated with greater benefit.
Methods: We analyzed patients enrolled in POINT with minor ischemic stroke who had available data recording the treatment initiation time and modified Rankin Scale (mRS) at 90 days.
Purpose: The purpose of the study was to design a pan-cancer gene panel for childhood malignancies and validate it using clinically characterized patient samples.
Experimental Design: In addition to 5,275 coding exons, SJPedPanel also covers 297 introns for fusions/structural variations and 7,590 polymorphic sites for copy-number alterations. Capture uniformity and limit of detection are determined by targeted sequencing of cell lines using dilution experiment.