Publications by authors named "J Djordjevic"
Objective: The purpose of this study was to examine the association between uremic toxins, inflammation, depression and anxiety among hemodialysis patients in Montenegro.
Method: The cross-sectional study included 88 patients undergoing hemodialysis. Depression and anxiety symptoms were assessed by Patient Health Questionnaire (PHQ-9) and Beck Anxiety Inventory (BAI).
Many genetic studies have established the kinase activity of inositol phosphate multikinase (IPMK) is required for the synthesis of higher-order inositol phosphate signaling molecules, the regulation of gene expression and control of the cell cycle. These genetic studies await orthogonal validation by specific IPMK inhibitors, but no such inhibitors have been synthesized. Here, we report complete chemical synthesis, cellular characterization, structure-activity relationships and rodent pharmacokinetics of a novel series of highly potent IPMK inhibitors.
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- Inositol tris/tetrakis phosphate kinases (IPK), specifically Arg1 and Ipk2, are essential for virulence in human fungal pathogens, but it is unclear whether their catalytic activity or structural role is the key factor.
- Researchers created a non-functional version of Arg1 called dkArg1 to investigate the role of IPK activity, discovering that both dkArg1 and a deletion strain had significant virulence defects and were unable to survive at higher temperatures and respond to nutrient conditions.
- The study highlights that while IPK activity is crucial for fungal virulence, the pathway's function may have evolved differently in fungal pathogens, suggesting IPK could be a potential target for new antif