Regional distribution of ventilation at residual volume in induced bronchospasm.

The regional distribution of a bolus of gas inhaled at residual volume (RV) is attributed to regional airway closure and is responsible for the phase IV of the single-breath washout during the following deflation. As bronchospasm increases the range of airway opening pressures through the lung, the regional distribution of the bolus could change with effects on the shape of the single-breath washout. We investigated the regional distribution of boluses inhaled at RV and their single-breath washouts during methacholine-induced bronchospasm in prone dogs.

Disturbances in pulmonary mechanics during serotonin perfusion.

The effect of i.v. perfused serotonin (75 microgram.