Subcellular NAD pools are interconnected and buffered by mitochondrial NAD.

The coenzyme NAD is consumed by signalling enzymes, including poly-ADP-ribosyltransferases (PARPs) and sirtuins. Ageing is associated with a decrease in cellular NAD levels, but how cells cope with persistently decreased NAD concentrations is unclear. Here, we show that subcellular NAD pools are interconnected, with mitochondria acting as a rheostat to maintain NAD levels upon excessive consumption.

Gay Dreams: Exploring the Relationship Between Sexual Orientation and Dream Content in Men.

Although numerous individual factors influencing dream content have been explored, research on the link between sexual orientation and dreaming remains limited. This study examined this relationship among 119 German-speaking men (mean age = 31.97 years), including 55 homosexual and 64 heterosexual participants.

Risk factors for hyphema following goniotomy or trabecular bypass stent placement combined with phacoemulsification.

Purpose: To report the rates and risk factors for layered hyphemas after goniotomy (PG) and trabecular bypass stent (PTBS) surgery combined with phacoemulsification.

Methods: Patient data was obtained using a retrospective chart review from adult patients (18 years of age or older) undergoing either PG or PTBS at the West Virginia University Eye Institute between 2013 and 2023. Generalized estimating equations were used to identify significant predictors of layered hyphema on post-operative day one.