MixONat, a Software for the Dereplication of Mixtures Based on C NMR Spectroscopy.

Whether chemists or biologists, researchers dealing with metabolomics require tools to decipher complex mixtures. As a part of metabolomics and initially dedicated to identifying bioactive natural products, dereplication aims at reducing the usual time-consuming process of known compounds isolation. Mass spectrometry and nuclear magnetic resonance are the most commonly reported analytical tools during dereplication analysis.

[Spontaneous uterine rupture of an unscarred uterus during labor: case report and review of the literature].

Uterine rupture during labor is a serious and uncommon obstetrical complication that can lead to severe prognosis for the mother and her child if not immediately diagnosed and treated. Most spontaneous uterine ruptures occur during labor in parturients with a scarred uterus and are much rarer on an unscarred uterus. We report the case of a uterine rupture on unscarred uterus to a 32 year-old woman after a labor induced by intravaginal prostaglandin and intravenous ocytocine injection.

[Smoking and pregnancy: the role of the gynecologist-obstetrician and the obstetrical team].

Pregnancy is a particular period of life which changes the woman's smoking behavior. One-third of smoking women stop smoking spontaneously during this period and a large proportion request help with smoking cessation. Gynecologist-obstetricians who are concerned by the technical aspects of the pregnancy and other classical risk factors (gestational diabetes, hypertension) play an indispensable role, but together with the entire obstetrical team they must become more involved to fully take into account this toxic disease in their everyday practice.

[Irritable colon in children: dietary aspects].

Forty cases of irritable bowel syndrome with complete dietary histories were examined retrospectively. Included were infants and children aged 6 to 42 months, who had diarrhoea at least 4 weeks duration, a normal pattern of growth and no evidence of malabsorption or enteric infections. The majority (92.

[Diet in familial hypercholesterolemia type IIa. Grenoble survey 1983-1988].

In 19 children with familial hypercholesterolemia type IIa measures to reduce the amount of saturated fat and cholesterol in the diet lead to a mean decrease of cholesterolemia of 15%, thus confirming the favorable effect of the diet previously reported in the literature. However, there were large variations in the efficacy of the diet from no effect up to a 30% decrease. "Non-responders", in whom the diet was not effective, require treatment with drugs.