Publications by authors named "J Delpierre"
Article Synopsis
- Hepatocytes create structures called apical bulkheads that help manage pressure in bile canaliculi, especially during bile flow issues.
- Research shows that these bulkheads increase in response to bile flow obstruction, which can occur in conditions like primary sclerosing cholangitis (PSC).
- The findings indicate that these structures protect against elevated pressure, and their loss can lead to abnormal liver cell formations, linking canalicular pressure to liver disease progression.
Hepatocytes grow their apical surfaces anisotropically to generate a 3D network of bile canaliculi (BC). BC elongation is ensured by apical bulkheads, membrane extensions that traverse the lumen and connect juxtaposed hepatocytes. We hypothesize that apical bulkheads are mechanical elements that shape the BC lumen in liver development but also counteract elevated biliary pressure.
View Article and Find Full Text PDFLumen morphogenesis results from the interplay between molecular pathways and mechanical forces. In several organs, epithelial cells share their apical surfaces to form a tubular lumen. In the liver, however, hepatocytes share the apical surface only between adjacent cells and form narrow lumina that grow anisotropically, generating a 3D network of bile canaliculi (BC).
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- The study investigates how the permeability of phosphate ions at tight junctions in the liver affects the formation of cholesterol gallstones, particularly focusing on a protein called claudin-3 (Cldn3).
- Using Cldn3-knockout mice, researchers found that the absence of this protein increased the permeability of phosphate ions, leading to the creation of calcium phosphate cores, which are essential in gallstone formation.
- The findings suggest that elevated levels of phosphate ions, especially in conjunction with cholesterol overload, significantly contribute to the risk of developing cholesterol gallstones, shedding light on a new mechanism behind this common condition.
As the data in the literature concerning the vascularization of the pectoralis minor were conflicting, we conducted a new anatomic study on cadavers preliminary to clinical application of a pedicle flap for clavicular coverage in 3 patients. Twenty flaps were dissected, yielding numerous anatomic variations. In all cases, the principal arteries penetrated the muscle in its upper part, either posteriorly or posterolaterally.
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