Publications by authors named "J Delisle"
Umbilical cord blood (UCB) represents a valuable graft source in the absence of a human leukocyte antigen (HLA)-matched donor for hematopoietic cell transplantation (HCT). Donor-specific anti-HLA antibodies (DSAs), targeting grafts with mismatched HLA antigens, pose a significant obstacle by increasing the risk of primary graft failure, delayed engraftment, and decreased survival. Existing literature on HLA desensitization has primarily focused on haploidentical transplants, and there is a lack of experience regarding the optimal strategy in UCB transplantation.
View Article and Find Full Text PDFA Phase II, Open-Label Study of Lenalidomide and Dexamethasone Followed by Donor Lymphocyte Infusions in Relapsed Multiple Myeloma Following Upfront Allogeneic Stem Cell Transplant.
Curr Oncol
November 2024
Background: To date, the only potential curative treatment for multiple myeloma (MM) remains allogeneic (allo) hematopoietic cell transplant (HCT), although, most patients will eventually relapse. In relapsed patients, donor lymphocyte infusions (DLIs) have been reported to control disease, but the optimal strategy prior to and doses of DLIs remain unclear. With this study (NCT03413800), we aimed to investigate the efficacy and toxicity of lenalidomide and dexamethasome (Len/Dex) followed by escalating pre-determined doses of DLIs in MM patients who relapsed after allo HCT.
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- Chemotherapy and radiation can damage the gastrointestinal (GI) barrier, leading to serious side effects like fatigue, malnutrition, and sometimes death.
- Apraglutide, a GLP-2 analog, was tested in mice and found to improve survival rates and reduce weight loss after treatment with chemotherapy and during allogeneic transplantation.
- The study showed that apraglutide helps maintain GI health by preserving the structure of the GI mucosa and improving intestinal microbiota compared to those receiving chemotherapy alone.
Article Synopsis
- Multiple myeloma (MM) poses significant treatment challenges, particularly for high-risk patients, with allogeneic hematopoietic cell transplantation (HCT) often resulting in severe side effects and high mortality rates.
- This study investigates the safety and feasibility of using UM171-expanded cord blood transplantation combined with autologous HCT for patients with high-risk MM.
- Out of 20 enrolled patients, 19 successfully underwent the UM171 procedure, highlighting potential improvements in patient outcomes despite the historical issues associated with cord blood transplantation.
Although culturally appropriate care is vital to quality of care, many barriers exist to implementing culturally appropriate care in practice. Nurse leaders are in a position where they can act toward addressing some of the barriers and engage nursing staff in strategies to promote the implementation of culturally appropriate care practices on a unit. This article is an opinion piece wherein the authors illustrate leadership strategies that advocate for and nurture a practice where nursing staff are supported to apply their culturally appropriate skills in practice.
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