Publications by authors named "J Del Carpio"
Chimeric antigen receptor-T (CAR-T) cells directed against B-cell maturation antigen (BCMA) are an effective treatment for multiple myeloma (MM), but short persistence and frequent relapses are challenges for this immunotherapy. This lack of durability has been attributed to the premature terminal differentiation of CAR-T cells which prevents the formation of long-lived memory cells that maintain anti-tumour responses. To improve long-term efficacy, we used CRISPR/Cas9-mediated gene editing to ablate the expression of the transcription factor Blimp-1.
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- * The study introduces enhanced modeling techniques for neutrino flux and detector response, and it distinguishes between starting (inside) and throughgoing (outside) neutrino interaction events to improve energy resolution.
- * The findings indicate a best-fit point for the 3+1 model with sin²(2θ_{24})=0.16 and Δm_{41}²=3.5 eV², supporting previous studies while showing consistency with no evidence of sterile neutrinos, as reflected
Article Synopsis
- Anticoagulant-related nephropathy is a condition where excessive anticoagulant levels lead to blood in urine and can result in acute kidney injury and possibly chronic kidney disease.
- The case study highlights a 63-year-old patient who developed kidney problems after starting anticoagulant medication two months post-kidney transplant.
- The patient experienced graft dysfunction alongside elevated international normalized ratio (INR) levels, indicating a potential overdose of the anticoagulant.