Publications by authors named "J Declercq"
Background: Iliopsoas tenotomy is commonly used to address refractory groin pain resulting from iliopsoas tendinopathy. However, consensus and high-level research on its effectiveness are lacking, with concerns about poor outcomes and complications. Little is known of the effects of iliopsoas tenotomy on the peri-articular muscle envelope of the hip.
View Article and Find Full Text PDFImportance: Fostamatinib, a spleen tyrosine kinase inhibitor, has been reported to improve outcomes of COVID-19.
Objective: To evaluate the efficacy and safety of fostamatinib in adults hospitalized with COVID-19 and hypoxemia.
Design, Setting, And Participants: This multicenter, phase 3, placebo-controlled, double-blinded randomized clinical trial was conducted at 41 US sites and 21 international sites between November 17, 2021, and September 27, 2023; the last follow-up visit was December 31, 2023.
Lay perspectives are important in the recovery of patients with nonspecific pain as they influence levels of pain and patients' pain experiences. Although previous interactional research has focused on patients' unsolicited attempts to share their perspectives, health professions also employ specific techniques to solicit them. Physiotherapists are recommended to assess lay perspectives and include them in treatment.
View Article and Find Full Text PDFArticle Synopsis
- Vaccines need to encourage mucosal immunity to effectively prevent infection by respiratory viruses, but the impact of current mRNA COVID-19 vaccines on this type of immunity is not well understood.
- A study with 183 individuals revealed that repeated mRNA booster vaccinations significantly increased neutralizing antibodies in nasal secretions, suggesting a connection between nasal and serum antibody levels.
- Further research in a mouse model indicated that the antibodies linked to mucosal immunity come from the spleen and bone marrow and can migrate from the bloodstream to the respiratory mucosa, providing insights for future vaccine development.
Background: Patient-reported outcomes (PROs) are often used by clinicians to evaluate patient response to specialty medications used to treat multiple sclerosis (MS) and rheumatologic conditions. Identifying associations among PROs and patient characteristics could inform patient-centered treatment monitoring.
Objective: To examine the association among patient characteristics and PROs, including patient-reported adherence (defined as no missed doses), medication tolerance, patient perceived effectiveness, and health care resource utilization (HCRU; defined as emergency department visits or hospitalizations), for patients prescribed specialty medications in 2 health system specialty pharmacies.