Publications by authors named "J Decaestecker"

Article Synopsis
  • A case series highlights positive results for patients with gastrointestinal (GI) cancer characterized by deficient mismatch repair (dMMR) who underwent surgery to remove a single worsening tumor while undergoing immunotherapy.
  • The study shows that this combined approach of surgery and immunotherapy can lead to excellent patient outcomes.
  • These findings suggest that carefully selected patients with dMMR GI cancer may benefit significantly from this treatment strategy.
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A 69-year-old male with a past medical history of an Olfactory nerve meningioma and left-sided Bell's palsy presented with 6 weeks of lower abdominal pain and weight loss of 4 kg in 6 months. His current medications included acetylsalicylic acid 80 mg once daily, Amlodipine 5 mg once daily and Allopurinol 300 mg once daily. Physical examination was benign without signs of acute abdomen.

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Astrocyte dysfunction has previously been linked to multiple neurodegenerative disorders including Parkinson's disease (PD). Among their many roles, astrocytes are mediators of the brain immune response, and astrocyte reactivity is a pathological feature of PD. They are also involved in the formation and maintenance of the blood-brain barrier (BBB), but barrier integrity is compromised in people with PD.

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