Publications by authors named "J DeGroot"
Article Synopsis
- Metastatic Pituitary neuroendocrine tumors (PitNET) are rare and aggressive, making them difficult to treat; however, aggressive behavior is also observed in non-metastatic forms.
- A study at UCSF analyzed samples from multiple patients with different types of aggressive PitNETs, categorizing them according to international neuroendocrine neoplasm criteria and identifying various tumor lineages.
- High rates of disease progression and mortality were noted, along with concerning histopathological and molecular characteristics that could serve as indicators of tumor aggressiveness, suggesting a need for a new grading system.
Article Synopsis
- Caring for medically complex children (MCC) presents unique physical, financial, and emotional challenges for parents who often experience grief over their lost expectations for a healthy child.
- Using Miles' parental grief model, researchers interviewed 25 parent-caregivers on a podcast to gain insight into their experiences, including feelings of yearning, helplessness, and behavioral changes as they navigated their challenges.
- The study also revealed communication barriers and facilitators that influenced how parent-caregivers dealt with grief and ultimately found acceptance in their parenting reality.
Sterile alpha and toll/interleukin receptor motif-containing 1 (SARM1) is a critical regulator of axon degeneration that acts through hydrolysis of NAD following injury. Recent work has defined the mechanisms underlying SARM1's catalytic activity and advanced our understanding of SARM1 function in axons, yet the role of SARM1 signaling in other compartments of neurons is still not well understood. Here, we show in cultured hippocampal neurons that endogenous SARM1 is present in axons, dendrites, and cell bodies and that direct activation of SARM1 by the neurotoxin Vacor causes not just axon degeneration, but degeneration of all neuronal compartments.
View Article and Find Full Text PDFEnteroviruses are a leading cause of upper respiratory tract, gastrointestinal, and neurological infections. Management of enterovirus-related diseases has been hindered by the lack of specific antiviral treatment. The pre-clinical and clinical development of such antivirals has been challenging, calling for novel model systems and strategies to identify suitable pre-clinical candidates.
View Article and Find Full Text PDFPurpose: The blood-brain barrier (BBB) inhibits adequate dosing/penetration of therapeutic agents to malignancies in the brain. Low-intensity pulsed ultrasound (LIPU) is a safe therapeutic method of temporary BBB disruption (BBBD) to enhance chemotherapeutic delivery to the tumor and surrounding brain parenchyma for treatment of glioblastoma.
Experimental Design: We investigated if LIPU could enhance therapeutic efficacy of anti-PD-1 in C57BL/6 mice bearing intracranial GL261 gliomas, epidermal growth factor receptor variant III (EGFRvIII) chimeric antigen receptor (CAR) T cells in NSG mice with EGFRvIII-U87 gliomas, and a genetically engineered antigen-presenting cell (APC)-based therapy producing the T-cell attracting chemokine CXCL10 in the GL261-bearing mice.