Publications by authors named "J De La Fuente Aguado"
Background: Multiple studies have shown good results with the use of octogenarian donors in non-HCV recipients and its use is universally accepted worldwide. There are no studies analyzing differences between hepatitis C virus (HCV) and non-HCV recipients transplanted with donors≥80 years in the direct-action antivirals (DAA) period. The rate of liver transplantation (LT) using old donors is still low, and a change in the acceptance of these grafts could increase the liver pool available for LT.
View Article and Find Full Text PDFThe QuantiFERON-Monitor assay (QTF-Monitor) is intended to assess innate and adaptive immune responses by quantifying interferon (IFN)-γ release upon whole blood stimulation with a TLR7/8 agonist and an anti-CD3 antibody. We performed the QTF-Monitor in 126 kidney transplant recipients (KTRs) at different points during the first 6 post-transplant months. The primary outcome was overall infection, whereas secondary outcomes included bacterial infection, opportunistic infection and cancer.
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- Respiratory syncytial virus-associated acute respiratory infection (RSV-ARI) is increasingly affecting adults, leading to serious health issues, as shown in a study of 275 hospitalized patients.
- In this study, 11.2% of patients experienced poor outcomes, with certain factors increasing their risk, such as cognitive impairment, use of anticoagulants, and low oxygen saturation ratios upon hospital admission.
- Interestingly, receiving the flu vaccine in the current season was found to reduce the risk of poor outcomes, underscoring the importance of early risk assessment for RSV-ARI in the emergency department.
Article Synopsis
- The study aimed to assess the likelihood of recurrent Clostridioides difficile infection (CDI) in solid-organ transplant (SOT) recipients during the year following their transplant.
- Researchers analyzed data from 191 SOT patients who had their first CDI episode, finding a 12% recurrence rate and highlighting that severe CDI and metronidazole monotherapy significantly raised this risk.
- The findings suggest that using metronidazole alone increases the chances of a recurrence, indicating a need for improved treatment strategies to prevent repeated infections in these patients.
Article Synopsis
- The study investigates the genetic factors linked to severe COVID-19, specifically focusing on hospitalized cases in admixed Americans.
- Researchers conducted the largest genome-wide association study (GWAS) for COVID-19 hospitalization in this population, identifying four significant genetic associations, including two novel loci found in Latin Americans.
- The findings highlight the importance of including diverse populations in genomic research, aiming to improve understanding of genetic risks associated with COVID-19 across different ethnic groups.