Publications by authors named "J De Graaff"
Background: The GAS trial demonstrated evidence that most neurodevelopmental outcomes at 2 years and 5 years of age in infants who received a single general anaesthetic (GA) for elective inguinal herniorrhaphy were clinically equivalent when compared to infants who did not receive GA. More than 20% of the children in the trial had at least one subsequent anaesthetic exposure after their initial surgery. Using the GAS database, this study aimed to address whether multiple (2 or more) GA exposures compared to one or no GA exposure in early childhood were associated with worse neurodevelopmental outcomes at 5 years.
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- The study aimed to validate and recalibrate two risk prediction scores (PRAm and intrinsic surgical risk score) for assessing 30-day in-hospital mortality in pediatric patients using a large database from multiple hospitals.
- Results showed that while both scores had good discrimination (AUROC values), they produced many false positives and underperformed compared to original validations.
- Ultimately, the intrinsic surgical risk score was more effective than PRAm, but the findings suggest that relying solely on these scores might not significantly enhance patient outcome predictions.
Article Synopsis
- The study investigates the gene expression profiles of circulating CD14+ monocytes in patients with rheumatoid arthritis and interstitial lung disease (RA-ILD) to better understand the disease's pathogenesis.
- Researchers collected blood samples from various groups, including RA patients with and without lung disease, and those with idiopathic pulmonary fibrosis (IPF) and healthy controls, analyzing the RNA for gene expression differences.
- Findings revealed that monocytes in RA-ILD patients exhibited unique gene expression patterns, particularly in inflammation and fibrosis regulation, linking their immune features more closely to IPF than to RA without lung involvement, which could inform future therapeutic strategies.
Short-term Outcomes in Infants after General Anesthesia with Low-dose Sevoflurane/Dexmedetomidine/Remifentanil versus Standard-dose Sevoflurane (the TREX Trial).
Anesthesiology
December 2024
Background: The Trial Remifentanil DEXmedetomidine (TREX) trial aimed to determine whether, in children less than 2 yr old, low-dose sevoflurane/dexmedetomidine/remifentanil anesthesia is superior to standard-dose sevoflurane anesthesia in terms of global cognitive function at 3 yr of age. The aim of the current secondary analyses was to compare incidence of intraoperative hypotension and bradycardia, postoperative pain, time to recovery, need for treatment of intraoperative hypotension and bradycardia, incidence of light anesthesia and need for treatment, need for postoperative pain medications, and morbidity and mortality outcomes at 5 days between the two arms.
Methods: This phase III randomized active controlled, parallel group, assessor blinded, multicenter, superiority trial was performed in 20 centers in Australia, Italy, and the United States.
Age differences in inducible laryngeal obstruction in adult populations.
Ann Allergy Asthma Immunol
November 2024
Article Synopsis
- The study aimed to investigate how inducible laryngeal obstruction (ILO) symptoms vary among adults of different ages, using a sample of 67 patients over 16 years old confirmed to have ILO.
- Results showed that adults under 50 reported significantly more symptoms like shortness of breath and chest tightness compared to those 50 and older.
- The findings suggest that older adults might have less obvious ILO symptoms and anxiety, indicating a need for increased awareness and evaluation in this age group.