Publications by authors named "J De Buck"
Purpose: Proton therapy of moving targets is considered a challenge. At Maastro, we started treating lung cancer patients with proton therapy in October 2019. In this work, we summarise the developed treatment strategies and gained clinical experience from a physics point of view.
View Article and Find Full Text PDFThe synthesis of unprecedented triskelion-shaped hexa-peri-hexabenzocoronenes with C, C or D symmertry is reported. We present a new, five step synthetic access to tris-iodinated HBC derivatives carrying different solubilizing moieties (tert-butyl and mesityl), which serve as suitable building blocks for further functionalization. These molecules can undergo Sonogashira cross coupling reactions to obtain a series of seven ethynyl tris-substituted HBCs.
View Article and Find Full Text PDFBackground: Pain is reported in 66% of cancer patients with advanced disease. Adequate pain management is a cornerstone of comprehensive supportive cancer care.
Purpose: The purpose of this study was to assess pain management in Oncology Units in Belgium.
Article Synopsis
- The split trehalase biosensor is a new diagnostic tool made from engineered proteins that can activate when brought together by specific analytes, like glucose, without needing sample processing.
- Researchers aimed to create a version of split trehalase that works better at physiological pH, obtaining high-activity versions from *Cellvibrio* that have improved performance compared to the existing *E. coli* based systems.
- By modifying these split trehalases to reduce unwanted self-reassembly and boost their activity, the study showed potential for better clinical testing outcomes through enhanced biosensor capabilities.