Comparison of metallothionein (MT) and Ki-67 antigen expression in benign and malignant thyroid tumours.

Thyroid carcinomas are the most frequently occurring tumours in the endocrine system. Metallothioneins (MT) and Ki-67 proteins are present in intensely proliferating cells, and their expression has been observed in numerous tumours, including thyroid tumours. The purpose of this study was to analyse the relationship between intensity of MT expression and Ki-67 antigen on one hand and histological features of the examined thyroid tumours on the other.

Neuroendocrine tumours--analysis of own material--a nine--year retrospective study.

Background/aims: Neuroendocrine tumours are fairly rare neoplasms that require different treatments and have various prognoses. The aim of this study was to present the author's observations of the histological tumor types, occurrence and its surgical treatment.

Methodology: Thirty-five cases of neuroendocrine tumours were studied retrospectively in a 9-year period.

Retroperitoneal tumours--analysis of own clinical material--a six-year retrospective study.

Background/aims: Primary retroperitoneal tumours and retroperitoneal organs' tumours represent a variety of lesions that require different treatments and have various prognoses. The aim of this study was to present the author's observations of the histological tumors types occurrence and their surgical treatment.

Methodology: One hundred twenty-three cases of retroperitoneal tumours were studied retrospectively in a 6-year period.

Alterations of tumor necrosis factor-alpha and interleukin 6 production and activity of the reticuloendothelial system in experimental obstructive jaundice in rats.

Background: Immunological changes are well recognised in obstructive jaundice. The aim of this study was to monitor plasma tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) levels in rats with obstructive jaundice.

Methods: The ability of splenocytes and peritoneal exudate cells (PEC) to produce these cytokines both spontaneously and on induction with lipopolysaccharide (LPS), was compared in rats with and without obstructive jaundice (OJ).

[Clinical significance of oxidation and acetylation genetic polymorphism in patients with hyperthyreosis].

Introduction: The relationship between genetically determined polymorphic oxidation and acetylation and susceptibility to some disease was aroused much interest. The aim of our study was to evaluate whether patients with hyperthyreosis differ from healthy persons in their ability to oxidize sparteine and acetylate sulphadimidine as model drugs. Oxidation and acetylation were estimated in 48 patients with hiperthyreosis.