From Immunity to Neurogenesis: Toll-like Receptors as Versatile Regulators in the Nervous System.

Toll-like receptors (TLRs) are among the main components of the innate immune system. They can detect conserved structures in microorganisms and molecules associated with stress and cellular damage. TLRs are expressed in resident immune cells and both neurons and glial cells of the nervous system.

Cooled Radiofrequency Treatment for Radicular Pain Related to Lumbar Disc Herniation.

Background: Lower back and radicular pain are leading causes of disability and loss of quality of life, especially due to its high prevalence in the general population. Cooled radiofrequency treatment (CRT) has emerged as a novel non-invasive technique for the management of discogenic pain with safe and effective results. The aim of this study was to evaluate the effectiveness of CRT in the treatment of radicular pain secondary to a lumbar hernia in patients with chronic neuropathic pain after receiving conservative treatment that did not achieve adequate pain management.

Intrathecal Baclofen Infusion Pump for the Treatment of Painful Spastic Hemiplegia: A Case Report.

Painful spastic hemiplegia is a common sequel to a stroke in which patients rarely achieve optimal levels of pain control. Herein, we report the case of a 62-year-old woman with painful spasticity secondary to an ischemic stroke of 15 years' evolution who received multiple pharmacological treatments without reaching motor or pain management goals. After an adequate analgesic response to the intrathecal baclofen test, the placement of an electromechanical pump was decided, reaching an effective maintenance dose of 150 μg per day.

A Case Report on Spinal Neurostimulator Treatment for Painful Postsurgical Neuropathy of the Genitofemoral Nerve.

Painful postsurgical neuropathy is an adverse event inherent to a wide variety of surgical treatments, so its diagnosis and specialized treatment are essential to maintaining the quality of life of the people who suffer from it. We present the case of a 31-year-old male with neuropathy of the genitofemoral nerve diagnosed by electromyography, resulting in intractable left testicular and thigh pain associated with a recent history of ipsilateral inguinal hernioplasty. After assessment by pain medicine and motor and sensory tests, a neurostimulator was placed in T8-T9 with action at the L1-L2 level, as well as a simultaneous electrode in S3, generating optimal pain relief and recovery of functionality.

Acute Phrenic Neuropathy and Diaphragmatic Dysfunction as a Complication of COVID-19: A Report of Four Cases.

Among the neurological manifestations associated with coronavirus disease 2019 (COVID-19), neuropathies are rare. They have been associated with prolonged prostration and metabolic failure in a seriously ill patient. We present a case series of four Mexican patients diagnosed with diaphragmatic dysfunction due to phrenic neuropathy during acute COVID-19, documented by conduction velocities of the phrenic nerves.