Publications by authors named "J David Horwhat"
Article Synopsis
- - The study aimed to investigate the progression rates of Barrett's esophagus patients diagnosed with "indefinite for dysplasia" (IND) compared to those with low grade dysplasia (LGD), and to see how many IND diagnoses changed after follow-up endoscopy.
- - Researchers analyzed data from 2264 patients, identifying 83 with IND and 79 with LGD, finding that the annual progression rates to high grade dysplasia (HGD) and esophageal adenocarcinoma were low, with a combined incidence of 0.8% and a mean progression time of about 4.72 years.
- - The findings revealed that over half of IND patients experienced regression to nondysplastic epithelium
This paper presents commentaries on how endoluminal antireflux procedures compare to laparoscopic fundoplication; new endoscopic procedures being studied to treat refractory gastroesophageal reflux disease (GERD); the new Stretta; the relationship between obesity and proton pump inhibitor (PPI) resistance; data concerning acid hypersensitivity and sensory receptors (vallinoid, TRPV1) causing refractory GERD; whether microscopic esophagitis is relevant in determining symptoms of non-erosive reflux disease (NERD); how concomitant functional gastrointestinal disorders affect the PPI response in NERD; the evidence that a functional esophagus is associated with inflammatory bowel syndrome (IBS); the role of GABA agonists in the treatment of refractory GERD; the role of biofeedback and antidepressants in refractory GERD; and endoluminal fundoplication using the EsophyX device.
View Article and Find Full Text PDFThe dose of omeprazole required to achieve adequate intraesophageal acid suppression in patients with gastroesophageal junction specialized intestinal metaplasia and Barrett's esophagus.
Dig Dis Sci
August 2013
Background: The mainstay of medical therapy for Barrett's esophagus is normalization of esophageal acid exposure with proton pump inhibitors (PPIs). However, the optimal dose and whether once daily or twice daily is required for acid suppression is unknown.
Aim: The purpose of this study was to assess whether adequate intra-esophageal acid suppression could be achieved with once daily versus twice daily omeprazole in patients with gastroesophageal specialized intestinal metaplasia (GEJSIM), short-segment (SSBE) and long-segment Barrett's esophagus (LSBE).
Background & Aims: Recent population-based studies have shown a low risk of esophageal adenocarcinoma (EAC) in patients with nondysplastic Barrett's esophagus (NDBE). We evaluated whether persistence of NDBE over multiple consecutive surveillance endoscopic examinations could be used in risk stratification of patients with Barrett's esophagus (BE).
Methods: We performed a multicenter outcomes study of a large cohort of patients with BE.