Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a three-species synthetic gut community.

The composition of the human gut microbiome is well resolved, but predictive understanding of its dynamics is still lacking. Here, we followed a bottom-up strategy to explore human gut community dynamics: we established a synthetic community composed of three representative human gut isolates ( L1-82, A2-165 and S5a33) and explored their interactions under well-controlled conditions in vitro. Systematic mono- and pair-wise fermentation experiments confirmed competition for fructose and cross-feeding of formate.

Monostable multivibrators as novel artificial neurons.

Retriggerable and non-retriggerable monostable multivibrators are simple timers with a single characteristic, their period. Motivated by the fact that monostable multivibrators are implementable in large quantities as counters in digital programmable hardware, we set out to investigate their applicability as building blocks of artificial neural networks. We derive the nonlinear input-output firing rate relations for single multivibrator neurons as well as the equilibrium firing rate of large recurrent networks.

Bistability in a system of two species interacting through mutualism as well as competition: Chemostat vs. Lotka-Volterra equations.

We theoretically study the dynamics of two interacting microbial species in the chemostat. These species are competitors for a common resource, as well as mutualists due to cross-feeding. In line with previous studies (Assaneo, et al.

Do Optomechanical Metasurfaces Run Out of Time?

Artificially structured metasurfaces make use of specific configurations of subwavelength resonators to efficiently manipulate electromagnetic waves. Additionally, optomechanical metasurfaces have the desired property that their actual configuration may be tuned by adjusting the power of a pump beam, as resonators move to balance pump-induced electromagnetic forces with forces due to elastic filaments or substrates. Although the reconfiguration time of optomechanical metasurfaces crucially determines their performance, the transient dynamics of unit cells from one equilibrium state to another is not understood.