Functional ultrasound and brain connectivity reveal central nervous system compromise in Trembler-J mice model of Charcot-Marie-Tooth disease.

The Charcot-Marie-Tooth-1E (CMT1E) disease is typically described as a peripheral neuropathy in humans, causing decreased nerve conduction, spastic paralysis, and tremor. The Trembler-J (TrJ) mice serve as a high fidelity model of this disease. Here, we use functional ultrasound (fUS) and functional connectivity (FC) to analyze TrJ mice's brain activity during sensory stimulation and resting state experiments against wild type (WT) mice - the healthy counterpart.

Epidemiology of cat bites to people in Uruguay: Effects of the age and sex of the victim, season of the year, and the COVID-19 pandemic.

Background: Cat bites to people are an important public health problem. However, very little information exists on the epidemiology of people bitten by cats at the level of an entire country in Latin America. Additionally, the COVID-19 pandemic significantly influenced people's lives and their relationships with pets, which could potentially affect the frequency of people bitten by cats.

Additive interaction of disability with chronic conditions on mortality risk in middle-aged and older adults in Spain.

Background: Disability and chronic diseases are prevalent conditions associated with mortality, but little information is available on their potential synergistic effects.

Objective: This study aimed to describe additive interactions between disability and chronic diseases on mortality risk in middle-aged and older adults.

Methods: A representative cohort of 22,800 community-dwelling Spanish people aged 50 years or older were interviewed for disability with the Global Activity Limitation Indicator and specific chronic diseases in the 2011-12 and 2014 National Health Surveys and subsequently followed up for mortality.