Can abstract screening workload be reduced using text mining? User experiences of the tool Rayyan.

Background: One time-consuming aspect of conducting systematic reviews is the task of sifting through abstracts to identify relevant studies. One promising approach for reducing this burden uses text mining technology to identify those abstracts that are potentially most relevant for a project, allowing those abstracts to be screened first.

Objectives: To examine the effectiveness of the text mining functionality of the abstract screening tool Rayyan.

Analysis of cell-free fetal DNA in maternal blood for detection of trisomy 21, 18 and 13 in a general pregnant population and in a high risk population - a systematic review and meta-analysis.

Introduction: The aim of this study was to review the performance of non-invasive prenatal testing (NIPT) for detection of trisomy 21, 18 and 13 (T21, T18 and T13) in a general pregnant population as well as to update the data on high-risk pregnancies.

Material And Methods: Systematic review and meta-analysis. PubMed, Embase and the Cochrane Library were searched.

Longevity of posterior resin composite restorations in adults – A systematic review.

Objective: To conduct a systematic review of the literature on the longevity of posterior resin composite restorations in adults.

Material And Methods: A systematic literature search was conducted according to pre-determined criteria for inclusion and exclusion. The studies selected were prospective clinical trials with a minimum follow-up time of 4 years, 40 restorations per experimental group and an annual attrition rate of less than 5%.

Intraclonal variations among Streptococcus pneumoniae isolates influence the likelihood of invasive disease in children.

Background: Pneumococcal serotypes are represented by a varying number of clonal lineages with different genetic contents, potentially affecting invasiveness. However, genetic variation within the same genetic lineage may be larger than anticipated.

Methods: A total of 715 invasive and carriage isolates from children in the same region and during the same period were compared using pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing.

Pattern of accessory regions and invasive disease potential in Streptococcus pneumoniae.

Background: The invasive disease potential (IDP) of Streptococcus pneumoniae differs between serotypes, but the reason for this is unknown.

Methods: A total of 47 pneumococcal isolates from 13 serotypes with different IDPs in humans that belonged to 37 multilocus sequence types were compared by whole genome microarrays and mutant analyses.

Results: Approximately 34% of the genes were variable, including 95 genes previously shown by signature-tagged mutagenesis (STM) to be required for invasive disease in mice.