Publications by authors named "J Da"
Background: Oxidative stress-induced inflammation is a major pathogenic mechanism in sepsis-associated encephalopathy (SAE). We hypothesized that regulation of reactive oxygen species (ROS) by the neuropeptide orexin-A could prevent SAE-induced oxidative stress and inflammation. Therefore, the aim of this study was to investigate the effects of orexin-A on oxidative stress and inflammation in SAE in mice.
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- The study focuses on the impact of diabetes mellitus on end-stage renal disease in Guizhou, China, aiming to improve care for patients with diabetic nephropathy who require hemodialysis.
- A survey analyzed data from middle-aged and elderly patients, highlighting a higher prevalence in males and a concerning increase in complications with longer diabetes duration.
- The findings emphasize the need for early intervention and specialized healthcare policies to address the rapid disease progression and unique challenges faced by this high-risk group.
Simultaneous detection of multiple biomarkers is crucial to achieve specific and dynamic analysis of cellular senescence, given its intrinsic high heterogeneity. Current approaches for senescence detection largely rely on fluorescence imaging, but fluorescent probes inevitably suffer from issues including autofluorescence and spectral overlap when being applied for the simultaneous detection of multiple biomarkers. Herein, we report an alternative strategy and design activatable multiplexed senoprobes based on F NMR for dynamic monitoring of cellular senescence.
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