Synthesis and Excited State Proton Transfer (ESPT) Studies of 2-(6-Substitutedbenzo[d]Thiazol-2-Yl)Naphthalen-1-Ol Derivatives.

This study reports the rapid intramolecular proton transfer studies upon photo excitation of 2-(benzo[d]thiazol-2-yl)naphthalene-1-ol derivatives, yielding tautomer emission with large Stokes shift. Employing photophysical studies, density functional theory (DFT) and, time-dependent density functional theory (TD-DFT) methods, we scrutinize excited state intramolecular proton transfer (ESIPT) modulation over varying solvent polarities. Analysis of UV-Visible and fluorescence spectra, alongside exploration of hydrogen bond dynamics, reveals solvation effects on the excited state proton transfer process.

Influence of head and neck cancer exosomes on macrophage polarization.

Background: Tumor cells within the tumor microenvironment (TME) release exosomes that influence macrophage phenotypes, either pro-tumorigenic or anti-tumorigenic. This mechanism, especially in head and neck squamous cell carcinoma (HNSCC), remains poorly understood. This study investigates the role of HNSCC exosomes in macrophage polarization.

Effect of Music Therapy on Anxiety, Stress and Sedative Requirements in Patients Undergoing Lower Limb Orthopedic Surgery Under Spinal Anesthesia: A Randomized Controlled Study.

Background Music therapy is a safe, non-pharmacological way to help reduce anxiety, especially before surgery. It helps to calm the nervous system, promotes relaxation, and offers comfort by blocking outside noise and distracting from pain. This can be helpful in managing preoperative anxiety and symptoms like hypertension and tachycardia.

Repurposing of Empagliflozin as Cardioprotective Drug: An in-silico Approach.

Background: Drug repurposing involves investigating new indications or uses for drugs that have already been approved for clinical use. Empagliflozin is a C-glycosyl compound characterized by the presence of a beta-glucosyl residue. It functions as a sodium-glucose co-transporter 2 inhibitor and is utilized to enhance glycemic control in adults diagnosed with type 2 diabetes mellitus.

Cutaneous Wound-Healing Activity of Quercetin-Functionalized Bimetallic Nanoparticles.

Quercetin, a natural flavonol, is reported to have significant antioxidant and anti-inflammatory activity, which further aids in its good wound-healing properties via acting on acute as well as chronic inflammatory phases. The current study is focused on understanding the potential of the green-synthesized iron and zinc oxide bimetallic (i.e.