Specific risks and outcomes of octogenarians post-lung cancer resection: our 5-year experience.

Background: An increasingly large proportion of patients undergoing curative surgery for lung cancer, are octogenarians. We evaluated our short and long-term survival and adverse outcomes after oncological lung resections.

Methods: Octogenarians undergoing anatomical resection for confirmed or suspected lung cancer at a single-centre between January 2016 and December 2021 were included.

Noninflammatory Causes of Pulmonary Edema During Ex Vivo Lung Perfusion.

Ex vivo lung perfusion (EVLP) is used to evaluate donor lungs prior to lung transplantation. Development of pulmonary edema during EVLP is generally thought to represent inflammatory breakdown of the air-fluid barrier and these lungs are declined for transplant. We present the case of a donor lung that underwent stapled wedge resection during cold storage for air leak and the subsequent development of profound (∼650 mL) pulmonary edema around the staple line during EVLP.

Longitudinal Changes in Cardiovascular Health Among Young Adults With Overweight and Obesity.

Background: It is essential to understand factors influencing young adult cardiovascular health (CVH) to reduce morbidity and mortality.

Objective: Evaluate longitudinal changes in CVH among young adults in a weight management intervention.

Methods: Life's Essential 8 (LE8) metrics were calculated for young adults with overweight and obesity enrolled in a randomized controlled trial (n = 459).

A thermodynamic investigation into protein-excipient interactions involving different grades of polysorbate 20 and 80.

Developing stable biopharmaceutical formulations is of paramount importance and is typically achieved by incorporating surfactants as stabilising agents, such as polysorbate 20 and 80. However, little is known about the effect surfactant grade has on formulation stability. This study evaluates the effect of regular grade and Super-refined™ polysorbates 20 and 80 and their interaction with model proteins, namely β-lactoglobulin (β-Ig), human serum albumin (HSA) and immunoglobulin gamma (IgG), using isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC).

Sensitivity of cartilage mechanical behaviour to spatial variations in material properties.

Articular cartilage tissue exhibits a spatial dependence in material properties that govern mechanical behaviour. A mathematical model of cartilage tissue under one dimensional confined compression testing is developed for normal tissue that takes account of these variations in material properties. Modifications to the model representative of a selection of mechanisms driving osteoarthritic cartilage are proposed, allowing application of the model to both physiological and pathophysiological, osteoarthritic tissue.