Biomarkers.

Background: Growth Differentiation Factor 15 (GDF15) is a TGF-beta superfamily protein upregulated during immune-mediated stress responses. Peripheral GDF15 is linked to adverse aging across organ systems including the brain. Immune dysregulation is implicated in frontotemporal dementia (FTD) pathogenesis.

Biomarkers.

Background: Collection, storage, and distribution of human fluid biospecimens in a scientifically rigorous manner is challenging. It requires physical space availability and robust infrastructure. Nonetheless, it is key to contribute to research in Alzheimer's Disease and Related Disorders, including Frontotemporal Dementia (FTD).

Developing Topics.

Background: Core outcome sets (COS) are a set of outcomes which stakeholders agree should be collected and reported as part of a minimum dataset for studies in a clinical population. COS developed collaboratively with patients and other stakeholders encourage researchers to report outcomes which are considered important by affected individuals. COS may reduce heterogeneity of outcome selection allowing for better synthesis across studies (e.

Lyme disease periprosthetic joint infection.

Periprosthetic joint infection (PJI) is a devastating complication of total joint surgery. Surgical management of PJI has increased surgical risks and is costly to the healthcare system. This case study presents a unique clinical scenario involving a patient who was diagnosed with Lyme PJI at the total knee arthroplasty site after undergoing surgical management.

Fall Risk Assessment in Acute Rehabilitation: Comparison of Two Assessment Tools.

Purpose: Many fall risk assessment tools exist. However, few of these fall risk assessment tools have been tested in the acute rehabilitation setting. The purpose of our study was to compare the accuracy of the Hendrich II Fall Risk Model (HIIFRM) and Sunnyview Test Scale in predicting falls.