Publications by authors named "J D Steill"
Hypoimmune gene edited human pluripotent stem cells (hPSCs) are a promising platform for developing reparative cellular therapies that evade immune rejection. Existing first-generation hypoimmune strategies have used CRISPR/Cas9 editing to modulate genes associated with adaptive (e.g.
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- The blue whale is the largest animal ever known, making its genome a key subject for studying longevity and cancer resistance.
- Researchers created a detailed genome assembly of the blue whale using advanced sequencing methods and collaborated with databases like NCBI for annotation.
- Findings revealed significant gene amplifications linked to the blue whale's size and genetic variations between Pacific and Atlantic populations, highlighting the genome's potential for future biological and conservation studies.
During an immune response, macrophages systematically rewire their metabolism in specific ways to support their diversve functions. However, current knowledge of macrophage metabolism is largely concentrated on central carbon metabolism. Using multi-omics analysis, we identified nucleotide metabolism as one of the most significantly rewired pathways upon classical activation.
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- Sus scrofa domesticus (pigs) are valuable for biomedical research due to their physiological similarities to humans, making them excellent models for studying regenerative biology.
- Researchers developed transgene-free porcine induced pluripotent stem cells (PiPSCs) from pig fibroblasts using targeted protocols, allowing these cells to differentiate into various cell types and maintain their species-specific developmental characteristics.
- The establishment of a porcine in vitro segmentation clock model highlights the potential of transgene-free PiPSCs for advancing our understanding of mammalian development and disease while offering new avenues for transplantation research.