Publications by authors named "J D Shulman"
Background: Tramadol is an adulterant of illicit opioids. As it is a serotonin-norepinephrine reuptake inhibitor as well as a μ-opioid agonist, tramadol adulteration may worsen overdose signs and symptoms or affect the amount of naloxone patients receive.
Methods: This is a multicenter, prospective cohort of adult patients with suspected opioid overdoses who presented to one of eight United States emergency departments and were included in the Toxicology Investigators Consortium's Fentalog Study.
Advances in microarray and sequencing technologies have made possible the interrogation of biological processes at increasing levels of complexity. The underlying biomolecular networks contain large numbers of nodes, yet interactions within the networks are not known precisely. In the absence of accurate models, one may inquire if it is possible to find relationships between the states of such networks under external changes, and in particular, if such relationships can be model-independent.
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- Opioid overdose deaths in the U.S. have dramatically increased due to the rise of illicit fentanyl, which also raises the risk of HIV infection among those affected by injection drug use.
- A study analyzed data from 1,690 patients who experienced acute opioid overdoses across 10 hospitals to identify HIV prevalence and associated risk factors.
- The findings revealed that 5.6% of patients with known HIV status were HIV positive, with stimulant use being more common among HIV-positive individuals and a significant link found between bipolar psychiatric history and increased HIV risk.
Trends in chlorine and chloramine gas exposures reported to United States poison centers.
Clin Toxicol (Phila)
September 2024
Article Synopsis
- Research shows a significant rise in chlorine and chloramine gas exposures in the U.S. during and after the COVID-19 pandemic, with total cases increasing by 61% from 2015 to 2022, especially from 2019 to 2020.* -
- Out of 85,104 reported exposures, the majority (84.9%) occurred at home, with many being mild and requiring minimal treatment, while a small percentage led to hospital admissions (1%) or deaths (0.03%).* -
- The shift towards increased cleaning and disinfecting practices during the pandemic likely contributed to this ongoing issue, as many individuals continued these habits even as routines returned to normal.*
The accumulation of reactive oxygen species (ROS) is a common feature of tauopathies, defined by Tau accumulations in neurons and glia. High ROS in neurons causes lipid production and the export of toxic peroxidated lipids (LPOs). Glia uptake these LPOs and incorporate them into lipid droplets (LDs) for storage and catabolism.
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