Glioma is the most prevalent type of primary central nervous system cancer, while glioblastoma (GBM) is its most aggressive variant, with a median survival of only 15 months when treated with maximal surgical resection followed by chemoradiation therapy (CRT). CD133 is a potentially significant GBM biomarker. However, current clinical biomarker studies rely on invasive tissue samples.
View Article and Find Full Text PDFGlioblastoma (GBM) is a fatal brain tumor with limited treatment options. O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status is the central molecular biomarker linked to both the response to temozolomide, the standard chemotherapy drug employed for GBM, and to patient survival. However, MGMT status is captured on tumor tissue which, given the difficulty in acquisition, limits the use of this molecular feature for treatment monitoring.
View Article and Find Full Text PDFThe use of anthropogenic resources is becoming increasingly common as species adapt to human-induced environmental changes, but their use can expose species to new risks. Understanding how animals exploit these resources is important for guiding conservation management, particularly where species are threatened. The introduction of canola cropping to breeding areas of endangered Carnaby's cockatoo () has been attributed to an increase in the birds' reproductive success; however, the seed may be protein-limiting for nestling growth and its use by cockatoos has been implicated in the emergence of a new disease.
View Article and Find Full Text PDFAn error on the part of the authors in drafting resulted in Eq. (3) being incorrect in the published paper [Opt. Express25, 20612 (2017)10.
View Article and Find Full Text PDFThe hierarchical design of bio-based nanostructured materials such as bone enables them to combine unique structure-mechanical properties. As one of its main components, water plays an important role in bone's material multiscale mechanical interplay. However, its influence has not been quantified at the length-scale of a mineralised collagen fibre.
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