Publications by authors named "J D Shamblin"
Article Synopsis
- * SAB-163 is a new therapeutic treatment developed from transchromosomic bovine plasma, showing strong effectiveness against multiple hantavirus strains and extended bioavailability in animal models.
- * The treatment has demonstrated protective effects in hamsters when administered around the time of exposure and is now ready for phase 1 clinical trials after passing safety and efficacy tests.
In 2022, mpox virus (MPXV) spread worldwide, causing 99,581 mpox cases in 121 countries. Modified vaccinia Ankara (MVA) vaccine use reduced disease in at-risk populations but failed to deliver complete protection. Lag in manufacturing and distribution of MVA resulted in additional MPXV spread, with 12,000 reported cases in 2023 and an additional outbreak in Central Africa of clade I virus.
View Article and Find Full Text PDFWe report strong Zika virus (ZIKV) neutralizing antibody responses in African green monkeys (Chlorocebus sabaeus) up to 1,427 days after ZIKV exposure via the subcutaneous, intravaginal, or intrarectal routes. Our results suggest that immunocompetent African green monkeys previously infected with ZIKV are likely protected from reinfection for years, possibly life, and would not contribute to virus amplification during ZIKV epizootics.
View Article and Find Full Text PDFArticle Synopsis
- Lassa virus (LASV) causes Lassa fever, a severe hemorrhagic fever primarily found in certain African countries, and this study investigates its effects in cynomolgus macaques exposed to LASV via aerosol.
- The progression of the disease was observed, with gross lesions emerging by day 6 and systemic involvement becoming evident by that time as well, particularly in the pulmonary and hemolymphatic systems.
- The research highlights the timeline of viremia and histopathologic changes and provides an extensive atlas of these lesions, which can be used for comparison with other models of aerosolized Arenaviral diseases.
Smallpox was the most rampant infectious disease killer of the 20th century, yet much remains unknown about the pathogenesis of the variola virus. Using archived tissue from a study conducted at the Centers for Disease Control and Prevention we characterized pathology in 18 cynomolgus macaques intravenously infected with the Harper strain of variola virus. Six macaques were placebo-treated controls, six were tecovirimat-treated beginning at 2 days post-infection, and six were tecovirimat-treated beginning at 4 days post-infection.
View Article and Find Full Text PDF