Publications by authors named "J D Seigne"
Bladder cancer and therapy responses hinge on immune profiles in the tumor microenvironment (TME) and blood, yet studies linking tumor-infiltrating immune cells to peripheral immune profiles are limited. DNA methylation cytometry quantified TME and matched peripheral blood immune cell proportions. With tumor immune profile data as the input, subjects were grouped by immune infiltration status and consensus clustering.
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- The study investigates the relationship between immune cell subtypes and bladder cancer outcomes, uncovering potentially important prognostic information for managing recurrence and survival in patients.
- Researchers measured DNA methylation from peripheral blood to quantify various immune cell types and analyzed their associations with patient survival using statistical models.
- Results showed that higher CD8T memory cells correlated with better survival, while factors like age acceleration and certain neutrophil proportions were linked to worse outcomes, allowing for the classification of patient groups based on survival differences.
Objectives: The aim of this study was to determine the frequency and reasons for long-term opioid prescriptions (rxs) after surgery in the setting of guideline-directed prescribing and a high rate of excess opioid disposal.
Background: Although previous studies have demonstrated that 5% to 10% of opioid-naïve patients prescribed opioids after surgery will receive long-term (3-12 months after surgery) opioid rxs, little is known about the reasons why long-term opioids are prescribed.
Methods: We studied 221 opioid-naïve surgical patients enrolled in a previously reported prospective clinical trial which used a patient-centric guideline for discharge opioid prescribing and achieved a high rate of excess opioid disposal.
Background: Recent studies indicate that bladder cancer is among the top 10 most common cancers in the world (Saginala et al. 2022). Bladder cancer frequently reoccurs, and prognostic judgments may vary among clinicians.
View Article and Find Full Text PDFObjective: To quantify the short-term burden associated with continent diversion relative to ileal conduit creation.
Methods: Bladder cancer patients who underwent radical cystectomy in 2019 and 2020 were identified in the American College of Surgeons National Surgical Improvement Program database using current procedural terminology codes and pathology reports. Patients were grouped by urinary diversion performed: ileal conduit versus continent diversion (neobladder or cutaneous reservoir).