Enabling SENSE accelerated 2D CSI for hyperpolarized carbon-13 imaging.

As hyperpolarized (HP) carbon-13 (C) metabolic imaging is clinically translated, there is a need for easy-to-implement, fast, and robust imaging techniques. However, achieving high temporal resolution without decreasing spatial and/or spectral resolution, whilst maintaining the usability of the imaging sequence is challenging. Therefore, this study looked to accelerate HP C MRI by combining a well-established and robust sequence called two-dimensional Chemical Shift Imaging (2D CSI) with prospective under sampling and SENSitivity Encoding (SENSE) reconstruction.

A cryogenic 14-channel C receiver array for 3T human head imaging.

Purpose: This article presents a novel 14-channel receive-only array for C human head imaging at 3 T that explores the SNR gain by operating at cryogenic temperature cooled by liquid nitrogen.

Methods: Cryostats are developed to evaluate single-coil bench SNR performance and cool the 14-channel array with liquid nitrogen while having enough thermal insulation between the coils and the sample. The temperature distribution for the coil array is measured.

Trade-off between preamplifier noise figure and decoupling in MRI detectors.

Purpose: There is a limit to the maximum achievable preamplifier decoupling. In many cases, this level is not enough. To overcome this limit, the preamplifier noise figure can be compromised for further decoupling increase.

RF coil design for accurate parallel imaging on C MRSI using Na sensitivity profiles.

Purpose: To develop a coil-based method to obtain accurate sensitivity profiles in C MRI at 3T from the endogenous Na. An eight-channel array is designed for C MR acquisitions. As application examples, the array is used for two-fold accelerated acquisitions of both hyperpolarized C metabolic imaging of pig kidneys and the human brain.

Metabolic MRI with hyperpolarized [1-C]pyruvate separates benign oligemia from infarcting penumbra in porcine stroke.

Acute ischemic stroke patients benefit from reperfusion in a short time-window after debut. Later treatment may be indicated if viable brain tissue is demonstrated and this outweighs the inherent risks of late reperfusion. Magnetic resonance imaging (MRI) with hyperpolarized [1-C]pyruvate is an emerging technology that directly images metabolism.