Congenital hyperinsulinism in the Ukraine: a 10-year national study.

Introduction: Congenital Hyperinsulinism (CHI) has not been previously studied in Ukraine. We therefore aimed to elucidate the genetics, clinical phenotype, histological subtype, treatment and long-term outcomes of Ukrainian patients with CHI.

Methods: Forty-one patients with CHI were recruited to the Ukrainian national registry between the years 2014-2023.

Association of structured continuum emission with dynamic aurora.

Patterns of ionospheric luminosity provide a unique window into our complex, coupled space environment. The aurora, for example, indicates plasma processes occurring thousands of km away, depositing immense amounts of energy into our polar ionospheres. Here we show observations of structured continuum emission associated with the dynamic aurora.

Destructive Self-Leadership? Self-Leadership, Maladaptive Coping, and Stress in College Students.

Prior research has examined self-leadership as a proactive self-regulatory approach for the management of stress and anxiety in college students. However, little is known about the possible negative effects of self-regulatory approaches such as self-leadership. Using the transactional model of stress and coping and the interaction model of stress, anxiety, and coping as theoretical frameworks, this study investigates a parallel multiple mediation model of the relationship between self-leadership and state anxiety as mediated by adaptive coping behaviours and maladaptive coping behaviours in a sample of 143 undergraduate students.

Advancing Systemic Toxicity Risk Assessment: Evaluation of a NAM-based Toolbox Approach.

For many years, a method that allowed systemic toxicity safety assessments to be conducted without generating new animal test data, seemed out of reach. However, several different research groups and regulatory authorities are beginning to use a variety of in silico, in chemico and in vitro techniques to inform safety decisions. To manage this transition to animal-free safety assessments responsibly, it is important to ensure that the level of protection offered by a safety assessment based on new approach methodologies (NAMs), is at least as high as that provided by a safety assessment based on traditional animal studies.