Defect dynamics in cholesterics: beyond the Peach-Koehler force.

The Peach-Koehler force between disclination lines was originally formulated in the study of crystalline solids, and has since been adopted to provide a notion of interactions between disclination lines in nematic liquid crystals. Here, we argue that the standard formulation of this interaction force seemingly fails for materials where there is a symmetry-broken ground state, and suggest that this is due to the interaction between disclination lines and merons: non-singular yet non-trivial topological solitons. We examine this in the context of chiral nematic (cholesteric) liquid crystals, which provide a natural setting for studying these interactions due to their energetic preference for meron tubes in the form of double-twist cylinders.

Genetic Predisposition to Hematologic Malignancies.

Hematologic malignancies (HMs) have been increasingly recognized in association with an underlying genetic predisposition syndrome (GPS) in individuals of all ages. It is critical for hematology and oncology providers to be aware of the diagnostic findings, physical examination findings, and aspects of family history that raise suspicion for an underlying GPS. Moreover, recognition of how somatic gene panel testing, frequently done at the time of HM diagnosis, may raise suspicion for an underlying germline condition based on the mutation profile reported, is prudent.

Comparisons of Interapical Distance and Coronal Balance Measurements among Standing Positions in Participants with and without Adolescent Idiopathic Scoliosis Using 3D Ultrasound Imaging.

Study Design: Cross-sectional study.

Objective: The objective of this study was to quantify whether interapical distance and coronal balance measured on 3D ultrasound (3DUS) images differed among ten standing positions of participants with and without adolescent idiopathic scoliosis (AIS).

Summary Of Background Data: Apical vertebral translation (AVT) is an indicator of clinical symptoms and treatment outcomes in AIS.

Improving Mental Health and Well-Being Through the Paradym App: Quantitative Study of Real-World Data.

Background: With growing evidence suggesting that levels of emotional well-being have been decreasing globally over the past few years, demand for easily accessible, convenient, and affordable well-being and mental health support has increased. Although mental health apps designed to tackle this demand by targeting diagnosed conditions have been shown to be beneficial, less research has focused on apps aiming to improve emotional well-being. There is also a dearth of research on well-being apps structured around users' lived experiences and emotional patterns and a lack of integration of real-world evidence of app usage.

Umbrella review of economic evaluations of interventions for the prevention and management of healthcare-associated infections in adult hospital patients.

Introduction: Healthcare-associated infections result in worse outcomes for patients and greater financial burden. An estimated 4.8 million HCAIs occurred in hospitals across Europe in 2022-23.