Publications by authors named "J D Mocco"
Background: Ticagrelor, a P2Y12 inhibitor, offers a rapid onset and consistent platelet inhibition, making it a viable alternative for dual antiplatelet therapy (DAPT). The optimal ticagrelor dose for neurointerventional procedures, however, remains unclear. We report our experience with ticagrelor 60 mg twice daily plus aspirin 81 mg daily compared with the standard aspirin and clopidogrel regimen for intracranial stenting.
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- Surgical evacuation of intracerebral hemorrhage (ICH) performed early can lead to better functional outcomes, but doing it too quickly may cause significant risks like postoperative rebleeding.
- The study developed a 5-point grading scale to assess the severity of intraoperative bleeding during minimally invasive endoscopic techniques for ICH evacuation.
- Among 142 patients evaluated, results indicated that while early evacuation is associated with increased bleeding scores, it did not lead to worse long-term outcomes or increased postoperative rebleeding.
Article Synopsis
- Cangrelor, an intravenous P2Y12-receptor inhibitor, is compared to traditional antithrombotic medications like eptifibatide in patients undergoing endovascular thrombectomies (EVTs), with previous data being insufficient for direct comparison.
- A study reviewed clinical data from 1010 EVT patients who received either cangrelor or eptifibatide to assess safety and efficacy, focusing on outcomes like hemorrhagic conversion and functional status using scales like the mRS and NIHSS.
- Results showed that cangrelor was linked to a lower risk of hemorrhagic conversion and better functional outcomes at discharge and follow-up, indicating its potential benefits over GPIs in this specific medical context
Article Synopsis
- - Distal medium vessel occlusions (DMVOs) are responsible for 25-40% of acute ischemic stroke cases, but predictive models specifically for DMVO outcomes are not yet available
- - A retrospective study developed a machine learning model using clinical, lab, imaging, and treatment data from 164 DMVO patients to predict unfavorable outcomes at 90 days, achieving good prediction accuracy and calibration
- - The model identified key predictive factors like NIHSS score and history of malignancy, and a web application was created for personalized patient outcome predictions, highlighting the potential for better stroke care and personalized medicine.
Article Synopsis
- This study explores the predictive value of certain radiographic features for neurologic outcomes in patients with basilar artery occlusion (BAO) who undergo endovascular therapy, as prior trials only included specific patients based on prognostic scores.
- It analyzes data from a thrombectomy database, correlating various demographic factors and radiographic scoring systems (PCCS, BATMAN, pc-ASPECTS) with 90-day neurologic outcomes, finding that lower scores on PCCS and BATMAN were linked to worse outcomes.
- Results showed that 21.5% of patients had a good neurologic outcome after 90 days, with significant associations found between poor outcomes and existing infarcts in specific brain