Publications by authors named "J D Mejia"
Introduction: Recent trial-level meta-analyses have established disease-free survival (DFS) as a valid surrogate for overall survival (OS) in human epidermal growth factor receptor 2-negative (HER2-) breast cancer (BC), irrespective of disease stage, and in early-stage hormone receptor-positive (HR+)/HER2- BC. To advance the understanding of the association between additional DFS endpoints and OS, this study assessed the patient-level correlations between DFS and OS, invasive DFS (IDFS) and OS, and distant DFS (DDFS) and OS in Medicare beneficiaries with early-stage HER2- BC, overall and in subgroups of patients with HR+/HER2- BC and triple-negative BC (TNBC).
Methods: Patients with stages I-III HER2- BC aged ≥ 66 years were identified from SEER-Medicare data (2010-2019).
Evaluation of benefits beyond quantitative academic outputs is essential in determining translational research value. We used the Translational Science Benefits Model (TSBM) to examine the impact of the QUARTET USA trial using 30 benefits across 4 domains: Clinical, Community, Economic, and Policy. We found that the QUARTET USA trial demonstrated impact in six areas within the Clinical, and Community domains and had potential impact in two additional areas within the Community and Economic domains.
View Article and Find Full Text PDFAim: This study aimed to describe treatment patterns and quantify the economic impact of recurrence in early-stage human epidermal growth factor receptor 2 (HER2)-negative breast cancer (BC).
Materials & Methods: Medicare beneficiaries with stages I-III HER2-negative BC and lumpectomy or partial/total mastectomy were identified from SEER-Medicare data (2010-2019). Perioperative therapies were reported in the neoadjuvant and adjuvant setting.
The photoinduced molecular reorientation of liquid crystals (LCs) caused by their nonlinear optical responses has attracted much attention due to their large refractive index change, leading to promising applications in optical devices. This reorientation is typically induced by light irradiation above a threshold intensity and is temporary, with the initial orientation recovering unless the LCs are polymerized and cross-linked. Our report highlights the memory effect of molecular reorientation in LCs.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on a rare case where a patient's left vertebral artery originates from the left external carotid artery, highlighting its embryological background.
- - The case involved a 55-year-old male with sepsis who underwent CT and CT angiography, revealing a unique vertebral artery anatomy, while his right vertebral artery was underdeveloped (hypoplastic).
- - The findings indicate that such anatomical variations are usually asymptomatic but are important for medical professionals to recognize for accurate diagnosis and effective treatment planning.