Correlates of sexual dysfunction in men and women with multiple sclerosis.

Sexual dysfunction (SD) is an often overlooked disability in multiple sclerosis (MS). The purpose of this study was to investigate the relationship between SD and other disabilities in men and women with MS. The sample included 32 men and 219 women.

Psychometric testing of the Americanized version of the Guy's Neurological Disability Scale.

The Guy's Neurological Disability Scale (GNDS) was originally developed in the United Kingdom to measure disability in multiple sclerosis (MS). The purpose of this study was to test the reliability, validity, and sensitivity of the Americanized version of the GNDS. The following five research questions were considered: (1) Is there convergent validity of the Americanized version of the GNDS as evidenced by a significant relationship with the Short Form 36 (SF-36) and Activities of Daily Living Self-Care for MS Scale? (2) Does the Americanized version of the GNDS have the same four-factor structure as reported in the psychometric testing of the original GNDS? (3) Is the Americanized version of the GNDS a reliable measure when examined with a 2-week retest? (4) Does the Americanized version of the GNDS have internal consistency? (5) Is the Americanized version of the GNDS sensitive to changes in neurological disability from MS over time? Participants were diagnosed with relapsing-remitting MS and a history of one or more relapses in the previous 2 years.

pH dependence of mitomycin C-induced cross-linking activity in EMT6 tumor cells.

Mitomycin C (MC), a quinone-containing bioreductive alkylating agent, is cytotoxic to aerobic EMT6 tumor cells despite the fact that little bioactivation of MC occurs in EMT6 cell homogenates in the presence of O2. Because spontaneous activation of MC at acidic pH has been reported in chemical systems, aerobic EMT6 tumor cells were incubated in serum-free 2-(N-morpholino)ethanesulfonic acid or N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid buffer at pH 5.7, 6.