Publications by authors named "J D McArthur"

The role of the clerkship director has evolved significantly over the past century and now requires a diverse range of skills to meet the rigorous standards set by national accrediting bodies such as the Liaison Committee on Medical Education. We conducted a historical exploration, spanning the past 43 years, of the educational practices in the Neurology Department at Johns Hopkins University School of Medicine. We learned that no entity is responsible for documenting the history of the clerkship.

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Background/objectives: Hematopoietic stem cell transplantation (HSCT) in pediatric and young adult (YA) patients can lead to endotheliopathy, such as thrombotic microangiopathy (TMA), sinusoidal obstruction syndrome (SOS), and diffuse alveolar hemorrhage (DAH). Natriuretic peptides have been studied as markers of endotheliopathy and critical illness. We hypothesized that an elevation in NT-proBNP was associated with the development of endotheliopathy (DAH, SOS, or TMA) in the first 100 days following HSCT in pediatric and YA patients.

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Article Synopsis
  • The study aimed to investigate the prevalence of squeezable food pouches among infants and young children, and their potential effects on energy intake and body mass index (BMI).
  • Researchers surveyed 933 children in New Zealand, and found that while pouch usage decreased as children grew older, the effect on their energy intake varied by age.
  • Notably, preschool children who frequently used pouches consumed less energy compared to non-users, while no significant differences in BMI were observed related to pouch use, suggesting concerns about pouches may be overstated.
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  • - Preclinical studies show that human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) can help repair injured hearts, with multiple clinical trials underway.
  • - Ventricular arrhythmias (EAs) can occur after injecting PSC-CMs into the heart, linked to cellular diversity within the transplanted cells, particularly arrhythmogenic subpopulations like atrial and pacemaker-like cardiomyocytes.
  • - Identifying specific surface markers may help differentiate risky PSC-CMs from safer ones, and both drug treatments and other interventions can help manage or eliminate these arrhythmias in the experimental model used.
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