Publications by authors named "J D Liporace"
The Neurodevelopmental Effects of Antiepileptic Drugs (NEAD) Study was a prospective observational multicenter study in the USA and UK, which enrolled pregnant women with epilepsy on antiepileptic drug (AED) monotherapy from 1999 to 2004. The study aimed to determine if differential long-term neurodevelopmental effects exist across four commonly used AEDs (carbamazepine, lamotrigine, phenytoin, and valproate). In this report, we examine fetal AED exposure effects on learning and memory functions in 221 six-year-old children (including four sets of twins) whose mothers took one of these AEDs during pregnancy.
View Article and Find Full Text PDFImportance: Breastfeeding is known to have beneficial effects, but concern exists that breastfeeding during maternal antiepileptic drug (AED) therapy may be harmful. We previously noted no adverse effects of breastfeeding associated with AED use on IQ at age 3 years, but IQ at age 6 years is more predictive of school performance and adult abilities.
Objectives: To examine the effects of AED exposure via breastfeeding on cognitive functions at age 6 years.
Article Synopsis
- The NEAD study is an observational research project from the USA and UK that followed pregnant women on antiepileptic drugs (AEDs) between 1999 and 2004 to assess the long-term neurodevelopmental effects on their children.
- It focused on four common AEDs—carbamazepine, lamotrigine, phenytoin, and valproate—evaluating 195 children at age six for adaptive and emotional/behavioral functioning.
- Results showed that children exposed to valproate during pregnancy had poorer adaptive functioning and a higher risk for ADHD compared to those exposed to lamotrigine and phenytoin, highlighting the need for awareness among women with epilepsy who require AEDs.*
Background: Many women of childbearing potential take antiepileptic drugs, but the cognitive effects of fetal exposure are uncertain. We aimed to assess effects of commonly used antiepileptic drugs on cognitive outcomes in children up to 6 years of age.
Methods: In this prospective, observational, assessor-masked, multicentre study, we enrolled pregnant women with epilepsy on antiepileptic drug monotherapy (carbamazepine, lamotrigine, phenytoin, or valproate) between October, 1999, and February, 2004, at 25 epilepsy centres in the UK and the USA.
Offspring of women with epilepsy (WWE) on AEDs are at increased risks for major congenital malformations and reduced cognition. They may be at risk for other adverse neonatal outcomes. Women with epilepsy on carbamazepine (CBZ), lamotrigine (LTG), phenytoin (PHT), or valproate (VPA) monotherapy were enrolled in a prospective, observational, multicenter study of the neurodevelopmental effects of AEDs.
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