Publications by authors named "J D Lay"
Article Synopsis
- This study explores how combining a hydrogen-producing microbiome with phytoremediation improves the breakdown of diesel in contaminated soil, focusing on enhanced enzyme activity.
- Key soil changes included increased moisture from 12.5% to 20%, a shift in pH to an alkaline level of 8.0-8.5, and improved organic matter, all supporting microbial activity.
- The combined approach achieved a 78.1% reduction in total petroleum hydrocarbons, significantly outperforming traditional methods, while also boosting microbial populations and Bermuda grass survival rates.
The inter- and intra-tumor heterogeneity of triple negative breast cancers (TNBC), which is reflected in diverse drug responses, interplays with tumor evolution. Here, we developed a preclinical experimental and analytical framework using treatment-naive TNBC patient-derived tumor xenografts (PDTX) to test their predictive value in personalized cancer treatment approaches. Patients and their matched PDTX exhibited concordant drug responses to neoadjuvant therapy using two trial designs and dosing schedules.
View Article and Find Full Text PDFBackground: Affect recall is key to psychological assessment and decision-making. However, self-concepts (self-beliefs) may bias retrospective affect reports such that they deviate from lived experiences. Does this experience-memory gap apply to solitude experiences? We hypothesized that individuals misremember how they feel overall and when in solitude, in line with self-concepts of introversion, self-determined/not-self-determined solitude motivations, and independent/interdependent self-construal.
View Article and Find Full Text PDFChemotherapy remains a cornerstone in lung cancer treatment, yet emerging evidence suggests that sublethal low doses may inadvertently enhance the malignancy. This study investigates the paradoxical effects of sublethal low-dose chemotherapy on non-small-cell lung cancer (NSCLC) cells, emphasizing the role of Aldo-keto reductase family 1 member B10 (AKR1B10). We found that sublethal doses of chemotherapy unexpectedly increased cancer cell migration approximately 2-fold and invasion approximately threefold, potentially promoting metastasis.
View Article and Find Full Text PDFArticle Synopsis
- Atrazine disrupts the formation of laminin and reduces germ and Sertoli cells in the developing testes of tammar wallabies, similar to the effects of oestrogen.
- The study highlights how exposure to atrazine (a banned herbicide in Europe) affects the balance of androgen and oestrogen, resulting in testis differentiation issues.
- The research involved treating male pouch young with atrazine and comparing its effects with other endocrine disruptors, revealing significant negative impacts on cell structure and function.