Publications by authors named "J D Lathia"
Background: Biological sex is an important risk factor for glioblastoma (GBM), with males having a higher incidence and poorer prognosis. The mechanisms for this sex bias are thought to be both tumor intrinsic and tumor extrinsic. MicroRNAs (miRNAs), key posttranscriptional regulators of gene expression, have been previously linked to sex differences in various cell types and diseases, but their role in the sex bias of GBM remains unknown.
View Article and Find Full Text PDFThe glioblastoma (GBM) microenvironment is enriched in immunosuppressive factors that potently interfere with the function of cytotoxic T lymphocytes. Cancer cells can directly impact the immune system, but the mechanisms driving these interactions are not completely clear. Here we demonstrate that the polyamine metabolite spermidine (SPD) is elevated in the GBM tumor microenvironment.
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- Radiation therapy is a common treatment for primary brain tumors, but it may lead to significant sleep disorders that haven't been fully explored.
- A systematic review analyzed 38 studies involving nearly 2,948 patients, finding a high incidence of sleep disturbances particularly from the end of radiation to six months afterward, linked to radiation dosage.
- The review calls for more research on sleep disorders in patients with primary brain tumors and suggests that pharmacological interventions can help manage sleep symptoms, despite inconsistencies in how these symptoms are reported across studies.
Immunotherapy for glioblastoma: current state, challenges, and future perspectives.
Cell Mol Immunol
December 2024
Glioblastoma (GBM) is an aggressive and lethal type of brain tumor in human adults. The standard of care offers minimal clinical benefit, and most GBM patients experience tumor recurrence after treatment. In recent years, significant advancements have been made in the development of novel immunotherapies or other therapeutic strategies that can overcome immunotherapy resistance in many advanced cancers.
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- Patients with brain tumors want to help doctors understand their illness better by participating in tests that involve taking samples of their tumor tissue.
- To improve treatments, everyone including patients, researchers, and regulatory agencies need to work together and use consistent methods when taking these samples.
- Even though new tests using blood samples show some promise, they can't replace the need for the usual tissue tests just yet, and it's important to clearly explain the risks and benefits of these procedures to patients.