Trajectory of peripheral inflammation during index ECT in association with clinical outcomes in treatment-resistant depression.

Background: Electroconvulsive therapy (ECT) is a highly efficacious intervention for severe and intractable depression. Evidence suggests ECT provokes an initial acute inflammatory response that subsequently decreases with repeated administration. However, relationships between inflammatory changes and clinical effects are unclear.

Critical reflection on the indication for computed tomography: an interdisciplinary survey of risk and benefit management in patients with sepsis.

Objectives: To survey physicians' views on the risks and benefits of computed tomography (CT) in the management of septic patients and indications for and contraindications to contrast media use in searching for septic foci.

Methods: A web-based questionnaire was administered to physicians at a large European university medical center in January 2022. A total of 371 questionnaires met the inclusion criteria and were analyzed with physicians' work experience, workplace, and medical specialty as independent variables.

Subcortical brain iron and its link to verbal memory in children with developmental language disorder.

Developmental Language Disorder (DLD) is a common neurodevelopmental condition characterized by significant difficulty with language learning, comprehension, and expression. The neurocognitive bases of DLD are underspecified but are thought to be related, in part, to altered basal ganglia (BG). The BG are known to have a high level of brain iron, which contributes to myelination and dopaminergic pathways among other physiological mechanisms.

Somatic symptom disorder and the role of epistemic trust, personality functioning and child abuse: Results from a population-based representative German sample.

Background: A growing body of evidence explored symptom burden of somatic symptom disorder (SSD) and its complex etiology involving psychosocial aspects. Child abuse has been linked to numerous psychopathologies including somatic symptoms as well as impaired personality functioning and disruptions in epistemic trust. This work aims to investigate personality functioning and epistemic trust in the association between child abuse and somatic symptom burden.